© 2019 Enabling Technologies Consortium

Compact HPLC

November 4, 2019

High performance liquid chromatography (HPLC) is a nearly universal analytical tool in organic synthesis and biochemical development laboratories. With the advent of commercially available automated sample extraction and dilution systems for heterogeneous systems (e.g. Mettler EasySampler, GlobalFIA FloPro, etc.), process development laboratories are increasingly moving towards automated analyses during synthetic route development and scale-up. Automated measurement enables unattended operation with consistent sampling at regularly scheduled intervals, increasing data density and leading to more efficient process understanding. A current limitation of the technology is related to analysis using conventional liquid chromatography systems. The chromatography system must be located proximal to the extraction and analysis or transferred over large distances. The former requirement imposes restrictions in confined spaces near the face of the laminar flow hoods where these studies are typically undertaken, and the latter approach imposes additional transfer time while increasing the risk of hold-up or carryover between successive samples. The ETC desires an integrated system (sample preparation and analysis) in a compact form factor that would enable mounting inside a lab hood. Depending on configuration, a compact system might enable “on demand” operation, due to minimal dead volume and small volume components that could quickly equilibrate prior to performing measurement. 

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Download the Request for Information and submit your response.

RFI ISSUED NOVEMBER 4, 2019

QUESTIONS DUE DECEMBER 9, 2019

RESPONSES DUE JANUARY 7, 2020